Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interaction between Genetic Risk Scores for reduced pulmonary function and smoking, asthma and endotoxin.

Thorax - 1 Dec 2021

Sikdar Sinjini, Wyss Annah B, Lee Mi Kyeong, Hoang Thanh T, Richards Marie, Beane Freeman Laura E, Parks Christine, Thorne Peter S, Hankinson John L, Umbach David M, Motsinger-Reif Alison, London Stephanie J

Abstract excerpt

RATIONALE: Genome-wide association studies (GWASs) have identified numerous loci associated with lower pulmonary function. Pulmonary function is strongly related to smoking and has also been associated with asthma and dust endotoxin. At the individual SNP level, genome-wide analyses of pulmonary function have not identified appreciable evidence for gene by environment interactions. Genetic Risk Scores (GRSs) may...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Asthma
Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endotoxins

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Polymorphism, Single Nucleotide

Share to Risk Factors

Share to Smoking

Source

Open in PubMed Open full text

Identifiers

PMID: 33963087
DOI: 10.1136/thoraxjnl-2020-215624
PMCID: PMC8572320

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interaction between Genetic Risk Scores for reduced pulmonary function and smoking, asthma and endotoxin.PMID 33963087Read ↗

Genome-wide gene-air pollution interaction analysis of lung function in 300,000 individualsSemantic proximity Read ↗

Smoking Interaction with a Polygenic Risk Score for Reduced Lung FunctionSemantic proximity Read ↗

Evidence for large-scale gene-by-smoking interaction effects on pulmonary function.Semantic proximity Read ↗

Genome-wide gene-air pollution interaction analysis of lung function in 300,000 individualsSemantic proximity Read ↗

Gene-environment interactions in the study of asthma in the postgenomewide association studies era.Semantic proximity Read ↗

Gene-Environment Interactions in Asthma: Genetic and Epigenetic Effects.Semantic proximity Read ↗

Genetic susceptibility to respiratory health effects from outdoor air pollution: a structured narrative review.Semantic proximity Read ↗

Gene-air pollution interactions in asthma.Semantic proximity Read ↗

A cross-sectional study of oxidative stress pathway genotypes and their interactions with environmental pollutant levels identifies associations with gene expression and lung function.Semantic proximity Read ↗

Exploring the genetic effects of exposure to hazardous workplaces on the risk of respiratory disease by two-sample mendelian randomization and bioinformatics analysis.Semantic proximity Read ↗

Gene-environment interactions in asthma and other respiratory diseases.Semantic proximity Read ↗

Gene by environment interaction in asthma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.