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Article

Effect of 6p21 region on lung function is modified by smoking: a genome-wide interaction study.

Scientific reports - 4 Aug 2020

Park Boram, An Jaehoon, Kim Wonji, Kang Hae Yeon, Koh Sang Baek, Oh Bermseok, Jung Keum Ji, Jee Sun Ha, Kim Woo Jin, Cho Michael H, Silverman Edwin K, Park Taesung, Won Sungho

Abstract excerpt

Smoking is a major risk factor for chronic obstructive pulmonary disease (COPD); however, more than 25% of COPD patients are non-smokers, and gene-by-smoking interactions are expected to affect COPD onset. We aimed to identify the common genetic variants interacting with pack-years of smoking on FEV1/FVC ratios in individuals with normal lung function. A genome-wide interaction study (GWIS) on FEV1/FVC was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32753590
DOI: 10.1038/s41598-020-70092-0
PMCID: PMC7403370

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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