Article
SCOPA and META-SCOPA: software for the analysis and aggregation of genome-wide association studies of multiple correlated phenotypes.
BMC bioinformatics - 11 Jan 2017
Mägi Reedik, Suleimanov Yury V, Clarke Geraldine M, Kaakinen Marika, Fischer Krista, Prokopenko Inga, Morris Andrew P
Abstract excerpt
BACKGROUND: Genome-wide association studies (GWAS) of single nucleotide polymorphisms (SNPs) have been successful in identifying loci contributing genetic effects to a wide range of complex human diseases and quantitative traits. The traditional approach to GWAS analysis is to consider each phenotype separately, despite the fact that many diseases and quantitative traits are correlated with each other, and often...
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