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Article

Statistical power and utility of meta-analysis methods for cross-phenotype genome-wide association studies.

PloS one - 1 Jan 2018

Zhu Zhaozhong, Anttila Verneri, Smoller Jordan W, Lee Phil H

Abstract excerpt

Advances in recent genome wide association studies (GWAS) suggest that pleiotropic effects on human complex traits are widespread. A number of classic and recent meta-analysis methods have been used to identify genetic loci with pleiotropic effects, but the overall performance of these methods is not well understood. In this work, we use extensive simulations and case studies of GWAS datasets to investigate the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 29494641
DOI: 10.1371/journal.pone.0193256
PMCID: PMC5832233

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