Article
Antagonistic Functions of MBP and CNP Establish Cytosolic Channels in CNS Myelin.
Cell reports - 10 Jan 2017
Snaidero Nicolas, Velte Caroline, Myllykoski Matti, Raasakka Arne, Ignatev Alexander, Werner Hauke B, Erwig Michelle S, Möbius Wiebke, Kursula Petri, Nave Klaus-Armin, Simons Mikael
Abstract excerpt
The myelin sheath is a multilamellar plasma membrane extension of highly specialized glial cells laid down in regularly spaced segments along axons. Recent studies indicate that myelin is metabolically active and capable of communicating with the underlying axon. To be functionally connected to the neuron, oligodendrocytes maintain non-compacted myelin as cytoplasmic nanochannels. Here, we used high-pressure...
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