Article
Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination.
Nature genetics - 1 Mar 2003
Lappe-Siefke Corinna, Goebbels Sandra, Gravel Michel, Nicksch Eva, Lee John, Braun Peter E, Griffiths Ian R, Nave Klaus-Armin
Abstract excerpt
Myelination of axons by oligodendrocytes enables rapid impulse propagation in the central nervous system. But long-term interactions between axons and their myelin sheaths are poorly understood. Here we show that Cnp1, which encodes 2',3'-cyclic nucleotide phosphodiesterase in oligodendrocytes, is essential for axonal survival but not for myelin assembly. In the absence of glial cyclic nucleotide...
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