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Transcriptome of sessile serrated adenoma/polyps is associated with MSI-high colorectal cancer and decreased expression of CDX2.

Cancer medicine - 1 Dec 2022

Ohki Daisuke, Yamamichi Nobutake, Sakaguchi Yoshiki, Takahashi Yu, Kageyama-Yahara Natsuko, Yamamichi Mitsue, Takeuchi Chihiro, Tsuji Yosuke, Sakai Yasuhiro, Sakurai Kouhei, Tomida Shuta, Koike Kazuhiko, Fujishiro Mitsuhiro

Abstract excerpt

The objective of this study was to elucidate the molecular background of sessile serrated adenoma/polyp (SSA/P) endoscopically resected with comprehensive gene expression analysis. Gene expression profiling was performed for 10 tumor-normal pairs of SSA/P. Cluster analysis, gene set enrichment analysis (GSEA), and consensus molecular subtype (CMS) classification of colorectal cancer (CRC) were applied to our...

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PMID: 35535692
DOI: 10.1002/cam4.4810
PMCID: PMC9761061

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