Article
Serrated Colorectal Cancer: The Road Less Travelled?
Trends in cancer - 1 Nov 2019
Nakanishi Yuki, Diaz-Meco Maria T, Moscat Jorge
Abstract excerpt
Studies of colorectal cancer (CRC) originating through the conventional adenoma-carcinoma sequence have provided insight into the molecular mechanisms controlling its initiation and progression. Less is known about the alternative 'serrated' pathway, which has been associated with BRAF mutation and microsatellite instability. Recent transcriptomics approaches to classify human CRC revealed that mesenchymal and/or...
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