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PP2A in LepR+ mesenchymal stem cells contributes to embryonic and postnatal endochondral ossification through Runx2 dephosphorylation

2 Jun 2021

Abstract excerpt

Abstract It has not been well studied which cells and related mechanisms contribute to endochondral ossification. Here, we fate mapped the leptin receptor-expressing (LepR + ) mesenchymal stem cells (MSCs) in different embryonic and adult extremities using Lepr-cre; tdTomato mice and investigated the underling mechanism using Lepr-cre; Ppp2r1a fl/fl mice. Tomato + cells appear in the primary and secondary...

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PMID: 34079065
DOI: 10.1038/s42003-021-02175-1

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