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Article

PERK is essential for neonatal skeletal development to regulate osteoblast proliferation and differentiation.

Journal of cellular physiology - 1 Dec 2008

Wei Jianwen, Sheng Xiaoyi, Feng Daorong, McGrath Barbara, Cavener Douglas R

Abstract excerpt

Loss of function mutations of Perk (eukaryotic translation initiation factor 2 alpha kinase 3) in humans and mice cause severe neonatal developmental defects, including diabetes, growth retardation and multiple skeletal dysplasias. Comprehensive analyses on bone tissue, at the cellular and molecular level in PERK-deficient mice demonstrated that neonatal Perk-/- mice are severely osteopenic, which is caused by a...

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Share to Activating Transcription Factor 4
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18683826
DOI: 10.1002/jcp.21543

Genes

CDK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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