Article
Heritability and genomics of gene expression in peripheral blood.
Nature genetics - 1 May 2014
Wright Fred A, Sullivan Patrick F, Brooks Andrew I, Zou Fei, Sun Wei, Xia Kai, Madar Vered, Jansen Rick, Chung Wonil, Zhou Yi-Hui, Abdellaoui Abdel, Batista Sandra, Butler Casey, Chen Guanhua, Chen Ting-Huei, D'Ambrosio David, Gallins Paul, Ha Min Jin, Hottenga Jouke Jan, Huang Shunping, Kattenberg Mathijs, Kochar Jaspreet, Middeldorp Christel M, Qu Ani, Shabalin Andrey, Tischfield Jay, Todd Laura, Tzeng Jung-Ying, van Grootheest Gerard, Vink Jacqueline M, Wang Qi, Wang Wei, Wang Weibo, Willemsen Gonneke, Smit Johannes H, de Geus Eco J, Yin Zhaoyu, Penninx Brenda W J H, Boomsma Dorret I
Abstract excerpt
We assessed gene expression profiles in 2,752 twins, using a classic twin design to quantify expression heritability and quantitative trait loci (eQTLs) in peripheral blood. The most highly heritable genes (∼777) were grouped into distinct expression clusters, enriched in gene-poor regions, associated with specific gene function or ontology classes, and strongly associated with disease designation. The design...
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