Article
Association Between Human Pain-Related Genotypes and Variability in Opioid Analgesia: An Updated Review.
Pain practice : the official journal of World Institute of Pain - 1 Jul 2015
Nielsen Lecia M, Olesen Anne E, Branford Ruth, Christrup Lona L, Sato Hiroe, Drewes Asbjørn M
Abstract excerpt
On an individual level, there is a difference in the analgesic response to a given opioid. Various factors such as gender, age, and genetic variation can affect the analgesic response. The genetic variation can influence pharmacokinetics (eg drug transporters and drug-metabolizing enzymes) and/or pharmacodynamics (eg opioid receptor and catechol-O-methyltransferase enzymes). We present recent experimentally...
Topics
Join the communities discussing this publication.