HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans.

doi:10.1056/NEJMoa1013297

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Article

HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans.

The New England journal of medicine - 24 Mar 2011

McCormack Mark, Alfirevic Ana, Bourgeois Stephane, Farrell John J, Kasperavičiūtė Dalia, Carrington Mary, Sills Graeme J, Marson Tony, Jia Xiaoming, de Bakker Paul I W, Chinthapalli Krishna, Molokhia Mariam, Johnson Michael R, O'Connor Gerard D, Chaila Elijah, Alhusaini Saud, Shianna Kevin V, Radtke Rodney A, Heinzen Erin L, Walley Nicole, Pandolfo Massimo, Pichler Werner, Park B Kevin, Depondt Chantal, Sisodiya Sanjay M, Goldstein David B, Deloukas Panos, Delanty Norman, Cavalleri Gianpiero L, Pirmohamed Munir

Abstract excerpt

BACKGROUND: Carbamazepine causes various forms of hypersensitivity reactions, ranging from maculopapular exanthema to severe blistering reactions. The HLA-B*1502 allele has been shown to be strongly correlated with carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN) in the Han Chinese and other Asian populations but not in European populations. METHODS: We performed a...

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Identifiers

PMID: 21428769
DOI: 10.1056/NEJMoa1013297
PMCID: PMC3113609

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