Shared peptide binding of HLA Class I and II alleles associate with cutaneous nevirapine hypersensitivity and identify novel risk alleles.

doi:10.1038/s41598-017-08876-0

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Article

Shared peptide binding of HLA Class I and II alleles associate with cutaneous nevirapine hypersensitivity and identify novel risk alleles.

Scientific reports - 17 Aug 2017

Pavlos Rebecca, McKinnon Elizabeth J, Ostrov David A, Peters Bjoern, Buus Soren, Koelle David, Chopra Abha, Schutte Ryan, Rive Craig, Redwood Alec, Restrepo Susana, Bracey Austin, Kaever Thomas, Myers Paisley, Speers Ellen, Malaker Stacy A, Shabanowitz Jeffrey, Jing Yuan, Gaudieri Silvana, Hunt Donald F, Carrington Mary, Haas David W, Mallal Simon, Phillips Elizabeth J

Abstract excerpt

Genes of the human leukocyte antigen (HLA) system encode cell-surface proteins involved in regulation of immune responses, and the way drugs interact with the HLA peptide binding groove is important in the immunopathogenesis of T-cell mediated drug hypersensitivity syndromes. Nevirapine (NVP), is an HIV-1 antiretroviral with treatment-limiting hypersensitivity reactions (HSRs) associated with multiple class I and...

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Identifiers

PMID: 28819312
DOI: 10.1038/s41598-017-08876-0
PMCID: PMC5561238

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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