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Article

A novel loss-of-function heterozygous BRCA2 c.8946_8947delAG mutation found in a Chinese woman with family history of breast cancer.

Journal of cancer research and clinical oncology - 1 Apr 2017

Ma Jing, Yang Jichun, Jian Wenjing, Wang Xianming, Xiao Deyong, Xia Wenjun, Xiong Likuan, Ma Duan

Abstract excerpt

INTRODUCTION: Breast cancer is the most frequent female malignancy worldwide. Among them, some cases have hereditary susceptibility in two leading genes, BRCA1 and BRCA2. Heterozygous germ line mutations in them are related with increased risk of breast, ovarian and other cancer, following autosomal dominant inheritance mode. METHODS AND RESULTS: For purpose of early finding, early diagnosis and early treatment,...

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Identifiers

PMID: 28058502
DOI: 10.1007/s00432-016-2327-9

Genes

BRCA2
BRCA1

Variants

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