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Four novel BRCA variants found in Chinese hereditary breast cancer patients by next-generation sequencing.

Clinica chimica acta; international journal of clinical chemistry - 1 May 2021

Liu Peng-Fei, Zhuo Zhong-Ling, Xie Fei, Wang Shu, Zhao Xiao-Tao

Abstract excerpt

Breast cancer is the most frequent cancer among women worldwide. Patients carrying mutations in breast cancer susceptibility genes like BRCA1 and BRCA2 (BRCA1/2) account for 5-10% of all breast cancer patients. Therefore, screening for susceptibility genes may reduce the incidence of breast cancer and improve prognosis. To provide evidence for mutation interpretation and targeted drug use in breast cancer...

Topics

BRCA1 Protein
BRCA2 Protein
Breast Neoplasms
China
Female
Genes, BRCA1
Genes, BRCA2
Genetic Predisposition to Disease
High-Throughput Nucleotide Sequencing
Humans

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PMID: 33476590
DOI: 10.1016/j.cca.2021.01.010

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