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Article

Characterization of the pathogenic mechanism of a novel BRCA2 variant in a Chinese family.

Familial cancer - 1 Jan 2008

Kwong Ava, Wong L P, Chan K Y K, Ma E S K, Khoo U S, Ford J M

Abstract excerpt

INTRODUCTION: Germline mutations of BRCA1 and BRCA2 account for the majority of hereditary breast cancers, many of which are classified as variants of unknown significance (VUS). We report the identification of a novel BRCA2 variant (c.7806-9T > G) in a Chinese family with multiple breast cancers and document it as a pathogenic mutation. METHODS: The proband in this family was diagnosed with breast cancer at age...

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Source

Identifiers

PMID: 17657584
DOI: 10.1007/s10689-007-9155-7

Genes

BRCA2
BRCA1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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