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Article

A comprehensive focus on global spectrum of BRCA1 and BRCA2 mutations in breast cancer.

BioMed research international - 1 Jan 2013

Karami Fatemeh, Mehdipour Parvin

Abstract excerpt

Breast cancer (BC) is the most common cancer of women all over the world. BRCA1 and BRCA2 gene mutations comprise the most important genetic susceptibility of BC. Except for few common mutations, the spectrum of BRCA1 and BRCA2 mutations is heterogeneous in diverse populations. 185AGdel and 5382insC are the most important BRCA1 and BRCA2 alterations which have been encountered in most of the populations. After...

Topics

BRCA1 Protein
BRCA2 Protein
Breast Neoplasms
Female
Founder Effect
Genes, BRCA1
Genes, BRCA2
Genetic Predisposition to Disease
Genetic Variation
Genetics, Population
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutagenesis, Insertional

Mutant Proteins

Mutation

Polymorphism, Genetic

Sequence Deletion

Source

Open in PubMed Open full text

Identifiers

PMID: 24312913
DOI: 10.1155/2013/928562
PMCID: PMC3838820

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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