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Novel germline mutations and unclassified variants of BRCA1 and BRCA2 genes in Chinese women with familial breast/ovarian cancer.

BMC cancer - 6 Feb 2016

Cao Wen-Ming, Gao Yun, Yang Hong-Jian, Xie Shang-Nao, Ding Xiao-Wen, Pan Zhi-Wen, Ye Wei-Wu, Wang Xiao-Jia

Abstract excerpt

BACKGROUND: Germline mutations in the BRCA1 and BRCA2 genes greatly increase a woman's risk of developing breast and/or ovarian cancer. The prevalence and distribution of such mutations differ across races/ethnicities. Several studies have investigated Chinese women with high-risk breast cancer, but the full spectrum of the mutations in these two genes remains unclear. METHODS: In this study, 133 unrelated...

Topics

Adult
Aged
Asian People
BRCA1 Protein
BRCA2 Protein
Breast Neoplasms
China
Female
Founder Effect
Genetic Predisposition to Disease
Germ-Line Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Haplotypes

Humans

Middle Aged

Ovarian Neoplasms

Pedigree

Source

Open in PubMed Open full text

Identifiers

PMID: 26852015
DOI: 10.1186/s12885-016-2107-6
PMCID: PMC4744435

Genes

BRCA1
BRCA2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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