Article
Retrospective reinterpretation and reclassification of BRCA1/2 variants from Chinese population.
Breast cancer (Tokyo, Japan) - 1 Nov 2020
Li Dan, Shi Yujian, Li Ang, Cao Dandan, Su Huijun, Yang Haiqi, Zhi Qihuan, Yang Yuchen, Lan Zhaoji, Zhou Tianliangwen, You Xiaobin, Hu Guifang
Abstract excerpt
BACKGROUND: The accurate interpretation of BRCA1/2 variants becomes increasingly important in breast cancer and other related cancers including ovarian cancer, prostate cancer, pancreatic cancer and so forth. In the past decades, especially before year 2015, limitations of techniques and lack of databases and guidelines have led to possible misinterpretation of the clinical significance of sequence variants of...
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