Comprehensive mutational analysis of BRCA1/BRCA2 for Korean breast cancer patients: evidence of a founder mutation.

doi:10.1111/j.1399-0004.2009.01202.x

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Back to search

Article

Comprehensive mutational analysis of BRCA1/BRCA2 for Korean breast cancer patients: evidence of a founder mutation.

Clinical genetics - 1 Aug 2009

Seong M-W, Cho Si, Noh D-Y, Han W, Kim S-W, Park C-M, Park H-W, Kim S Y, Kim J Y, Park S S

Abstract excerpt

The BRCA1 and BRCA2 genes are the strongest susceptibility genes identified for breast cancer worldwide. However, BRCA1/BRCA2 have been incompletely investigated due to their large size and the genomic rearrangements that occasionally occur within them. Here we performed a comprehensive mutational analysis for BRCA1/BRCA2 in 206 Korean patients with breast cancer. We analyzed all exons and flanking regions of...

Topics

Amino Acid Sequence
Asian People
BRCA1 Protein
BRCA2 Protein
Base Sequence
Breast Neoplasms
Conserved Sequence
DNA Mutational Analysis
Female
Founder Effect
Haplotypes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Korea

Molecular Sequence Data

Mutation

Polymorphism, Single Nucleotide

Sequence Alignment

Source

Open in PubMed

Identifiers

PMID: 19656164
DOI: 10.1111/j.1399-0004.2009.01202.x

Genes

BRCA2
BRCA1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comprehensive mutational analysis of BRCA1/BRCA2 for Korean breast cancer patients: evidence of a founder mutation.PMID 19656164Read ↗

Discovery of BRCA1/BRCA2 Founder Variants by Haplotype AnalysisSemantic proximity Read ↗

The prevalence and spectrum of BRCA1 and BRCA2 mutations in Korean population: recent update of the Korean Hereditary Breast Cancer (KOHBRA) study.Semantic proximity Read ↗

Discovery of BRCA1/BRCA2 founder variants by haplotype analysis.Semantic proximity Read ↗

Prevalence of BRCA1 and BRCA2 mutations in non-familial breast cancer patients with high risks in Korea: the Korean Hereditary Breast Cancer (KOHBRA) Study.Semantic proximity Read ↗

Spectra of BRCA1 and BRCA2 mutations in Korean patients with breast cancer: the importance of whole-gene sequencing.Semantic proximity Read ↗

Prevalence of BRCA1 and BRCA2 mutations in Korean breast cancer patients.Semantic proximity Read ↗

Germline Mutations of BRCA1 and BRCA2 in Korean Ovarian Cancer Patients: Finding Founder Mutations.Semantic proximity Read ↗

Characteristics and spectrum of BRCA1 and BRCA2 mutations in 3,922 Korean patients with breast and ovarian cancer.Semantic proximity Read ↗

The Korean Hereditary Breast Cancer Study: Review and Future PerspectivesSemantic proximity Read ↗

Comprehensive analysis of BRCA1 and BRCA2 germline mutations in a large cohort of 5931 Chinese women with breast cancer.Semantic proximity Read ↗

A novel loss-of-function heterozygous BRCA2 c.8946_8947delAG mutation found in a Chinese woman with family history of breast cancer.Semantic proximity Read ↗

Clinically Significant Unclassified Variants in BRCA1 and BRCA2 genes among Korean Breast Cancer Patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.