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Article

In silico analysis of the wild-type and mutant-type of BRCA2 gene.

Journal of translational medicine - 21 May 2024

Li Jingjing, Ge Rui, Lu Guanming, Cai Yuanxuan, Teng Yuan, Fan Zhe, Liao Liangyan, Kong Lingjie, Zhang Jinze, Wei Tao, Li Qian, Long Tianzhu, Yu Hongyan, Li Jie

Abstract excerpt

BACKGROUND: The aim of this study was to conduct an in silico analysis of a novel compound heterozygous variant in breast cancer susceptibility gene 2 (BRCA2) to clarify its structure-function relationship and elucidate the molecular mechanisms underlying triple-negative breast cancer (TNBC). METHODS: A tumor biopsy sample was obtained from a 42-year-old Chinese woman during surgery, and a maxBRCA™ test was...

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Identifiers

PMID: 38773604
DOI: 10.1186/s12967-024-05200-z
PMCID: PMC11110208

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