Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The in vitro PIG-A gene mutation assay: glycosylphosphatidylinositol (GPI)-related genotype-to-phenotype relationship in TK6 cells.

Archives of toxicology - 1 Jul 2016

Krüger Christopher T, Fischer Bettina M, Armant Olivier, Morath Volker, Strähle Uwe, Hartwig Andrea

Abstract excerpt

In our previous work, we established an in vitro variant of the currently developed in vivo PIG-A assay as promising mutagenicity test system. We applied the human B-lymphoblastoid cell line TK6 for the in vitro assay development, which is based on the cellular glycosylphosphatidylinositol (GPI) status. At least 22 genes are involved in GPI biosynthesis, leading to the complex situation that, in principle,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Culture Techniques
Share to Chromosome Deletion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 17

Share to Electrophoresis, Agar Gel

Share to Ethyl Methanesulfonate

Share to Glycosylphosphatidylinositols

Share to Mutagenicity Tests

Share to Ultraviolet Rays

Source

Identifiers

PMID: 27100116
DOI: 10.1007/s00204-016-1707-x

Genes

GPI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The in vitro PIG-A gene mutation assay: glycosylphosphatidylinositol (GPI)-related genotype-to-phenotype relationship in TK6 cells.PMID 27100116Read ↗

The in vitro PIG-A gene mutation assay: mutagenicity testing via flow cytometry based on the glycosylphosphatidylinositol (GPI) status of TK6 cells.Semantic proximity Read ↗

In vitro mammalian cell mutation assays based on the Pig-a gene: A report of the 7th International Workshop on Genotoxicity Testing (IWGT) Workgroup.Semantic proximity Read ↗

Development of an in vitro PIG-A gene mutation assay in human cells.Semantic proximity Read ↗

The PIG-A gene mutation assay in human biomonitoring and disease.Semantic proximity Read ↗

The PIG-A gene mutation assay in human biomonitoring and diseaseSemantic proximity Read ↗

[The PIG-A gene as a new biomarker of mutagenesis: proof of concept and technical specifications].Semantic proximity Read ↗

Glycosylphosphatidylinositol (GPI) anchored protein deficiency serves as a reliable reporter of Pig-a gene Mutation: Support from an in vitro assay based on L5178Y/Tk+/- cells and the CD90.2 antigen.Semantic proximity Read ↗

The use of PIG-A as a sentinel gene for the study of the somatic mutation rate and of mutagenic agents in vivo.Semantic proximity Read ↗

The in vivo Pig-a gene mutation assay, a potential tool for regulatory safety assessment.Semantic proximity Read ↗

Establishing a novel Pig-a gene mutation assay in L5178YTk+/- mouse lymphoma cells.Semantic proximity Read ↗

Erythrocyte-Based Pig-a Gene Mutation Assay.Semantic proximity Read ↗

Erythrocyte-based Pig-a gene mutation assay.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.