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Article

A quantitative-trait locus in the human factor XII gene influences both plasma factor XII levels and susceptibility to thrombotic disease.

American journal of human genetics - 1 Mar 2002

Soria José Manuel, Almasy Laura, Souto Juan Carlos, Bacq Delphine, Buil Alfonso, Faure Alexandra, Martínez-Marchán Elisabeth, Mateo José, Borrell Montserrat, Stone William, Lathrop Mark, Fontcuberta Jordi, Blangero John

Abstract excerpt

One approach to the identification of genetic loci that influence complex diseases is through the study of quantitative risk factors correlated with disease susceptibility. Factor XII (FXII) plasma levels, a related phenotype correlated with thrombosis, is such a risk factor. We conducted the first genomewide linkage screen to localize genes that influence variation in FXII levels. Two loci were detected: one on...

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Identifiers

PMID: 11805911
DOI: 10.1086/339259
PMCID: PMC384936

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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