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Article

Chlorogenic acid inhibits glioblastoma growth through repolarizating macrophage from M2 to M1 phenotype.

Scientific reports - 3 Jan 2017

Xue Nina, Zhou Qin, Ji Ming, Jin Jing, Lai Fangfang, Chen Ju, Zhang Mengtian, Jia Jing, Yang Huarong, Zhang Jie, Li Wenbin, Jiang Jiandong, Chen Xiaoguang

Abstract excerpt

Glioblastoma is an aggressive tumor that is associated with distinctive infiltrating microglia/macrophages populations. Previous studies demonstrated that chlorogenic acid (5-caffeoylquinic acid, CHA), a phenolic compound with low molecular weight, has an anti-tumor effect in multiple malignant tumors. In the present study, we focused on the macrophage polarization to investigate the molecular mechanisms behind...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28045028
DOI: 10.1038/srep39011
PMCID: PMC5206721

Genes

STAT1
STAT6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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