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Oleanolic acid inhibits macrophage differentiation into the M2 phenotype and glioblastoma cell proliferation by suppressing the activation of STAT3.

Oncology reports - 1 Dec 2011

Fujiwara Yukio, Komohara Yoshihiro, Kudo Rino, Tsurushima Keiichiro, Ohnishi Koji, Ikeda Tsuyoshi, Takeya Motohiro

Abstract excerpt

Tumor-associated macrophages (TAMs) polarized to the M2 phenotype promote tumor cell proliferation and are associated with a poor prognosis in patients with high grade glioma. We previously revealed that corosolic acid, a triterpenoid compound, inhibits the M2 polarization of human monocyte-derived macrophages (HMDM). In the present study, we examined whether...

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Identifiers

PMID: 21922144
DOI: 10.3892/or.2011.1454

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STAT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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