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Article

Combined microsatellite instability and BRAF gene status as biomarkers for adjuvant chemotherapy in stage III colorectal cancer.

Journal of surgical oncology - 1 Dec 2014

Ooki Akira, Akagi Kiwamu, Yatsuoka Toshimasa, Asayama Masako, Hara Hiroki, Takahashi Akemi, Kakuta Miho, Nishimura Yoji, Yamaguchi Kensei

Abstract excerpt

BACKGROUND: The clinical relevance of combined microsatellite instability (MSI) and BRAF status for adjuvant treatment in stage III colorectal cancer (CRC) remains elusive. METHODS: In 405 patients with curatively resected stage III CRC, the prognostic value of combined MSI and BRAF status was assessed in four groups, as follows: high-levels of microsatellite instability (MSI-H) and BRAF-wild type, MSI-H and...

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PMID: 25154726
DOI: 10.1002/jso.23755

Genes

BRAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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