KRAS and BRAF Mutations in Stage II and III Colon Cancer: A Systematic Review and Meta-Analysis.

doi:10.1093/jnci/djab190

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Article

KRAS and BRAF Mutations in Stage II and III Colon Cancer: A Systematic Review and Meta-Analysis.

Journal of the National Cancer Institute - 11 Apr 2022

Formica Vincenzo, Sera Francesco, Cremolini Chiara, Riondino Silvia, Morelli Cristina, Arkenau Hendrik-Tobias, Roselli Mario

Abstract excerpt

BACKGROUND: KRAS and BRAF mutations are well-established predictive and prognostic factors in metastatic colorectal cancer; however, their impact in the adjuvant setting has not yet been established. METHODS: We performed a meta-analysis of adjuvant phase III trials in patients with stage II and...

Topics

Colonic Neoplasms
Colorectal Neoplasms
Humans
Male
Microsatellite Instability
Mutation
Neoplasm Staging
Prognosis
Proto-Oncogene Proteins B-raf
Proto-Oncogene Proteins p21(ras)
Testicular Neoplasms

Source

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Identifiers

PMID: 34542636
DOI: 10.1093/jnci/djab190
PMCID: PMC9002292

Genes

BRAF
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-34542636-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

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Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.