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Article

URAT1 inhibition by ALPK1 is associated with uric acid homeostasis.

Rheumatology (Oxford, England) - 1 Apr 2017

Kuo Tzer-Min, Huang Chung-Ming, Tu Hung-Pin, Min-Shan Ko Albert, Wang Shu-Jung, Lee Chi-Pin, Ko Ying-Chin

Abstract excerpt

Objective: The aim of this study was to identify a protein for urate transporter 1 (URAT1) regulation. Methods: The clinical dataset consisted of 492 case-control samples of Han Chinese (104 gout and 388 controls). Three alpha kinase 1 ( ALPK1 ) and SLC22A12 loci associated with high gout risk and uric acid levels were genotyped. The overexpression of ALPK1 on URAT1 protein expression was evaluated in vivo in h...

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Topics

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Share to Crystallization
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hyperuricemia

Share to Kidney Tubules, Proximal

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Share to Organic Cation Transport Proteins

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Source

Identifiers

PMID: 28039413
DOI: 10.1093/rheumatology/kew463

Genes

ALPK1

Variants

rs11726117

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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