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Article

Common gene variants interactions related to uric acid transport are associated with knee osteoarthritis susceptibility.

Connective tissue research - 1 May 2019

Fernández-Torres Javier, Martínez-Nava Gabriela Angélica, Oliviero Francesca, López-Reyes Alberto Gabriel, Martínez-Flores Karina, Garrido-Rodríguez Daniela, Francisco-Balderas Adriana, Zamudio-Cuevas Yessica

Abstract excerpt

BACKGROUND: The presence of genetic variants in uric acid (UA) transporters can be associated with hyperuricemia, and therefore with an increased risk of monosodium urate (MSU) crystal precipitation. The inflammatory process triggered by these crystals leads to cartilage damage, which, in turn, could promote knee osteoarthritis (KOA). OBJECTIVE: To determine whether genetic polymorphisms of the UA transporters...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29855200
DOI: 10.1080/03008207.2018.1483359

Genes

GCKR
PDZK1
STC1
INHBB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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