Genome-wide association study for serum urate concentrations and gout among African Americans identifies genomic risk loci and a novel URAT1 loss-of-function allele.

doi:10.1093/hmg/ddr307

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Genome-wide association study for serum urate concentrations and gout among African Americans identifies genomic risk loci and a novel URAT1 loss-of-function allele.

Human molecular genetics - 15 Oct 2011

Tin Adrienne, Woodward Owen M, Kao Wen Hong Linda, Liu Ching-Ti, Lu Xiaoning, Nalls Michael A, Shriner Daniel, Semmo Mariam, Akylbekova Ermeg L, Wyatt Sharon B, Hwang Shih-Jen, Yang Qiong, Zonderman Alan B, Adeyemo Adebowale A, Palmer Cameron, Meng Yan, Reilly Muredach, Shlipak Michael G, Siscovick David, Evans Michele K, Rotimi Charles N, Flessner Michael F, Köttgen Michael, Cupples L Adrienne, Fox Caroline S, Köttgen Anna

Abstract excerpt

Serum urate concentrations are highly heritable and elevated serum urate is a key risk factor for gout. Genome-wide association studies (GWAS) of serum urate in African American (AA) populations are lacking. We conducted a meta-analysis of GWAS of serum urate levels and gout among 5820 AA and a large candidate gene study among 6890 AA and 21 708 participants of European ancestry (EA) within the Candidate Gene...

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PMID: 21768215
DOI: 10.1093/hmg/ddr307
PMCID: PMC3177647

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SGK1

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