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Article

Lymphocyte α-kinase is a gout-susceptible gene involved in monosodium urate monohydrate-induced inflammatory responses.

Journal of molecular medicine (Berlin, Germany) - 1 Dec 2011

Wang Shu-Jung, Tu Hung-Pin, Ko Albert Min-Shan, Chiang Shang-Lun, Chiou Shean-Jaw, Lee Su-Shin, Tsai Yi-Shan, Lee Chi-Pin, Ko Ying-Chin

Abstract excerpt

The molecular functions and pathophysiologic role of the lymphocyte α-kinase gene (ALPK1) in gout are unknown. We aimed to examine ALPK1 expression in patients with gout and investigate its role in monosodium urate monohydrate (MSU)-induced inflammatory responses. Microarray data mining was performed with six datasets containing three clinical gout and three volunteer samples. Real-time quantitative polymerase...

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Source

Identifiers

PMID: 21822924
DOI: 10.1007/s00109-011-0796-5

Genes

ALPK1
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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