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Ischemic stroke susceptibility associated with ALPK1 single nucleotide polymorphisms by inhibiting URAT1 in uric acid hemostasis.

Gene - 20 Jan 2025

Qiu Luying, Lu Xiaoqin, Xue Weishuang, Fu Hefei, Deng Shumin, Li Long, Chen Meilin, Wang Yanzhe

Abstract excerpt

OBJECTIVES: Ischemic stroke (IS) prevalence rising annually, the necessity of discovering non-interventional genetic influences is progressing. Single nucleotide polymorphism (SNP) plays a pivotal role in stable inheritance of disease susceptibility. Based on the relationship between Alpha- Kinase 1 (ALPK1) and traditional IS risk factors especially hyperuricemia, our study investigated the association and...

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PMID: 39437898
DOI: 10.1016/j.gene.2024.149017

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