Article
Common variant of ALPK1 is not associated with gout: a replication study.
Human cell - 1 Jan 2015
Chiba Toshinori, Matsuo Hirotaka, Sakiyama Masayuki, Nakayama Akiyoshi, Shimizu Seiko, Wakai Kenji, Suma Shino, Nakashima Hiroshi, Sakurai Yutaka, Shimizu Toru, Ichida Kimiyoshi, Shinomiya Nariyoshi
Abstract excerpt
Gout is one of the most kinds of common inflammatory arthritis as a consequence of hyperuricemia. Alpha-protein kinase 1 (ALPK1) gene locates in a gout-susceptibility locus on chromosome 4q21-31, and encodes ALPK1 protein which plays a pivotal role in the phosphorylation of myosin 1. In the previous genetic study of Taiwanese populations, 3 single nucleotide polymorphisms (SNPs), rs11726117, rs231247 and...
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