Article
Sodium-dependent phosphate cotransporter type 1 sequence polymorphisms in male patients with gout.
Annals of the rheumatic diseases - 1 Jun 2010
Urano Wako, Taniguchi Atsuo, Anzai Naohiko, Inoue Eisuke, Kanai Yoshikatsu, Yamanaka Mariko, Endou Hitoshi, Kamatani Naoyuki, Yamanaka Hisashi
Abstract excerpt
OBJECTIVES: Molecular biological approaches have recently identified urate transporters in renal proximal tubular cells. Human sodium-dependent phosphate cotransporter type 1 encoded by SLC17A1 is a urate transporter localised to the renal proximal tubular cells and candidate molecule to secret urate from renal tubular cells to urine. This study investigated the roles of SLC17A1 in the development of gout....
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