Genotypic tropism testing of proviral DNA to guide maraviroc initiation in aviraemic subjects: 48-week analysis of results from the PROTEST study.

doi:10.1111/hiv.12479

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Article

Genotypic tropism testing of proviral DNA to guide maraviroc initiation in aviraemic subjects: 48-week analysis of results from the PROTEST study.

HIV medicine - 1 Aug 2017

Poveda E, Hernández-Quero J, Pérez-Elías M J, Ribas M A, Martínez-Madrid O J, Flores J, Navarro J, Gutiérrez F, García-Deltoro M, Imaz A, Ocampo A, Artero A, Blanco F, Bernal E, Pasquau J, Mínguez-Gallego C, Pérez N, Aiestaran A, García F, Paredes R

Abstract excerpt

OBJECTIVES: Maraviroc (MVC) is a suitable drug for aviraemic subjects on antiretroviral treatment (ART) developing toxicity. Its prescription requires prior tropism testing. It is unknown if proviral DNA genotypic tropism testing is reliable for guiding MVC initiation in aviraemic subjects, so this study was carried out to address this issue. METHODS: PROTEST was a phase 4, prospective, single-arm clinical trial...

Topics

Adult
CCR5 Receptor Antagonists
Cyclohexanes
DNA, Viral
Female
Genotype
Genotyping Techniques
HIV-1
Humans
Maintenance Chemotherapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Maraviroc

Middle Aged

Prospective Studies

Proviruses

Spain

Treatment Outcome

Triazoles

Source

Open in PubMed

Identifiers

PMID: 28035758
DOI: 10.1111/hiv.12479

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