Article
HIV-1 tropism testing in subjects achieving undetectable HIV-1 RNA: diagnostic accuracy, viral evolution and compartmentalization.
PloS one - 1 Jan 2013
Pou Christian, Codoñer Francisco M, Thielen Alexander, Bellido Rocío, Pérez-Álvarez Susana, Cabrera Cecilia, Dalmau Judith, Curriu Marta, Lie Yolanda, Noguera-Julian Marc, Puig Jordi, Martínez-Picado Javier, Blanco Julià, Coakley Eoin, Däumer Martin, Clotet Bonaventura, Paredes Roger
Abstract excerpt
BACKGROUND: Technically, HIV-1 tropism can be evaluated in plasma or peripheral blood mononuclear cells (PBMCs). However, only tropism testing of plasma HIV-1 has been validated as a tool to predict virological response to CCR5 antagonists in clinical trials. The preferable tropism testing strategy in subjects with undetectable HIV-1 viremia, in whom plasma tropism testing is not feasible, remains uncertain....
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