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Article

Contribution of Secreted NADase and Streptolysin O to the Pathogenesis of Epidemic Serotype M1 Streptococcus pyogenes Infections.

The American journal of pathology - 1 Mar 2017

Zhu Luchang, Olsen Randall J, Lee Jessica D, Porter Adeline R, DeLeo Frank R, Musser James M

Abstract excerpt

Streptococcus pyogenes secretes many toxins that facilitate human colonization, invasion, and dissemination. NADase (SPN) and streptolysin O (SLO) are two toxins that play important roles in pathogenesis. We previously showed that increased production of SPN and SLO in epidemic serotype M1 and M89 S. pyogenes strains is associated with rapid intercontinental spread and enhanced virulence. The biological functions...

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Identifiers

PMID: 28034602
DOI: 10.1016/j.ajpath.2016.11.003
PMCID: PMC5397666

Genes

SPN

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