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Article

NAD+‐glycohydrolase acts as an intracellular toxin to enhance the extracellular survival of group A streptococci

1 Apr 2002

Abstract excerpt

Group A streptococci (GAS) produce several secreted products that are thought to enhance pathogenicity by facilitating spread of the organisms through host tissues. Two such products, streptolysin O (SLO) and NAD+-glycohydrolase, appear to be functionally linked, in that SLO is required for transfer of NAD+-glycohydrolase into epithelial cells. However, the effects of NAD+-glycohydrolase on host cells are largely...

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Identifiers

PMID: 11967084
DOI: 10.1046/j.1365-2958.2002.02876.x

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