Article
Evolutionary pathway to increased virulence and epidemic group A Streptococcus disease derived from 3,615 genome sequences.
Proceedings of the National Academy of Sciences of the United States of America - 29 Apr 2014
Nasser Waleed, Beres Stephen B, Olsen Randall J, Dean Melissa A, Rice Kelsey A, Long S Wesley, Kristinsson Karl G, Gottfredsson Magnus, Vuopio Jaana, Raisanen Kati, Caugant Dominique A, Steinbakk Martin, Low Donald E, McGeer Allison, Darenberg Jessica, Henriques-Normark Birgitta, Van Beneden Chris A, Hoffmann Steen, Musser James M
Abstract excerpt
We sequenced the genomes of 3,615 strains of serotype Emm protein 1 (M1) group A Streptococcus to unravel the nature and timing of molecular events contributing to the emergence, dissemination, and genetic diversification of an unusually virulent clone that now causes epidemic human infections worldwide. We discovered that the contemporary epidemic clone emerged in stepwise fashion from a precursor cell that...
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