Article
Molecular analysis of the role of streptococcal pyrogenic Exotoxin A (SPEA) in invasive soft-tissue infection resulting from Streptococcus pyogenes.
Molecular microbiology - 1 Aug 1999
Sriskandan S, Unnikrishnan M, Krausz T, Cohen J
Abstract excerpt
Epidemiological studies strongly implicate the bacterial superantigen, streptococcal pyrogenic exotoxin A (SPEA), in the pathogenesis of necrotizing soft-tissue infection and toxic shock syndrome resulting from Streptococcus pyogenes. SPEA can act as a superantigen and cellular toxin ex vivo, but its role during invasive streptococcal infection is unclear. We have disrupted the wild-type spea gene in an M1...
Topics
- Animals
- Bacterial Proteins
- Cells, Cultured
- Disease Models, Animal
- Exotoxins
- Humans
- Leukocyte Count
- Membrane Proteins
- Mice
- Mutation
- Neutrophils
- Oligodeoxyribonucleotides
- RNA, Messenger
- Staining and Labeling
- Streptococcal Infections
- Streptococcus pyogenes
- Transformation, Bacterial
- Virulence