Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular analysis of the role of streptococcal pyrogenic Exotoxin A (SPEA) in invasive soft-tissue infection resulting from Streptococcus pyogenes.

Molecular microbiology - 1 Aug 1999

Sriskandan S, Unnikrishnan M, Krausz T, Cohen J

Abstract excerpt

Epidemiological studies strongly implicate the bacterial superantigen, streptococcal pyrogenic exotoxin A (SPEA), in the pathogenesis of necrotizing soft-tissue infection and toxic shock syndrome resulting from Streptococcus pyogenes. SPEA can act as a superantigen and cellular toxin ex vivo, but its role during invasive streptococcal infection is unclear. We have disrupted the wild-type spea gene in an M1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Exotoxins
Share to Leukocyte Count
Share to Neutrophils

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Oligodeoxyribonucleotides

Share to Staining and Labeling

Share to Streptococcal Infections

Share to Streptococcus pyogenes

Share to Transformation, Bacterial

Source

Identifiers

PMID: 10447887
DOI: 10.1046/j.1365-2958.1999.01525.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular analysis of the role of streptococcal pyrogenic Exotoxin A (SPEA) in invasive soft-tissue infection resulting from Streptococcus pyogenes.PMID 10447887Read ↗

Analysis of the superantigenic activity of mutant and allelic forms of streptococcal pyrogenic exotoxin A.Semantic proximity Read ↗

Toxoids of streptococcal pyrogenic exotoxin A are protective in rabbit models of streptococcal toxic shock syndrome.Semantic proximity Read ↗

Toxins and Superantigens of Group A StreptococciSemantic proximity Read ↗

Streptococcal superantigen, mitogenic factor, and pyrogenic exotoxin B expressed by Streptococcus pyogenes. Structure and function.Semantic proximity Read ↗

The bacterial superantigen streptococcal mitogenic exotoxin Z is the major immunoactive agent of Streptococcus pyogenes.Semantic proximity Read ↗

Molecular analysis of pyrogenic exotoxins from Streptococcus pyogenes isolates associated with toxic shock-like syndrome.Semantic proximity Read ↗

Streptococcal pyrogenic exotoxin B enhances tissue damage initiated by other Streptococcus pyogenes products.Semantic proximity Read ↗

Mutations affecting MHC class II binding of the superantigen streptococcal erythrogenic toxin A.Semantic proximity Read ↗

Proinflammatory synergy between protease and superantigen streptococcal pyogenic exotoxinsSemantic proximity Read ↗

A novel superantigen isolated from pathogenic strains of Streptococcus pyogenes with aminoterminal homology to staphylococcal enterotoxins B and C.Semantic proximity Read ↗

Association of phenotypic and genotypic characteristics of invasive Streptococcus pyogenes isolates with clinical components of streptococcal toxic shock syndrome.Semantic proximity Read ↗

Geographic and temporal distribution and molecular characterization of two highly pathogenic clones of Streptococcus pyogenes expressing allelic variants of pyrogenic exotoxin A (Scarlet fever toxin).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.