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Article

Role of NADase in virulence in experimental invasive group A streptococcal infection.

Infection and immunity - 1 Oct 2005

Bricker Angela L, Carey Vincent J, Wessels Michael R

Abstract excerpt

Group A streptococci (GAS) produce several exoproteins that are thought to contribute to the pathogenesis of human infection. Two such proteins, streptolysin O (SLO) and NAD(+)-glycohydrolase (NADase), have been shown to interact functionally as a compound signaling toxin. When GAS are bound to the surface of epithelial cells in vitro, SLO forms pores in the cell membrane and delivers NADase to the epithelial...

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Identifiers

PMID: 16177331
DOI: 10.1128/IAI.73.10.6562-6566.2005
PMCID: PMC1230891

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