Article
Prophage exotoxins enhance colonization fitness in epidemic scarlet fever-causing Streptococcus pyogenes.
Nature communications - 6 Oct 2020
Brouwer Stephan, Barnett Timothy C, Ly Diane, Kasper Katherine J, De Oliveira David M P, Rivera-Hernandez Tania, Cork Amanda J, McIntyre Liam, Jespersen Magnus G, Richter Johanna, Schulz Benjamin L, Dougan Gordon, Nizet Victor, Yuen Kwok-Yung, You Yuanhai, McCormick John K, Sanderson-Smith Martina L, Davies Mark R, Walker Mark J
Abstract excerpt
The re-emergence of scarlet fever poses a new global public health threat. The capacity of North-East Asian serotype M12 (emm12) Streptococcus pyogenes (group A Streptococcus, GAS) to cause scarlet fever has been linked epidemiologically to the presence of novel prophages, including prophage ΦHKU.vir encoding the secreted superantigens SSA and SpeC and the DNase Spd1. Here, we report the molecular...
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