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NAD+-Glycohydrolase Promotes Intracellular Survival of Group A Streptococcus

3 Mar 2016

Abstract excerpt

A global increase in invasive infections due to group A Streptococcus (S. pyogenes or GAS) has been observed since the 1980s, associated with emergence of a clonal group of strains of the M1T1 serotype. Among other virulence attributes, the M1T1 clone secretes NAD+-glycohydrolase (NADase). When GAS binds to epithelial cells in vitro, NADase is translocated into the cytosol in a process mediated by streptolysin O...

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PMID: 26938870
DOI: 10.1371/journal.ppat.1005468

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