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Combined Contributions of Streptolysin O and Streptolysin S to Virulence of Serotype M5Streptococcus pyogenesStrain Manfredo

21 Jun 2003

Abstract excerpt

Streptolysin O (SLO) and streptolysin S (SLS) are potent cytolytic toxins produced by almost all clinical isolates of group A streptococci (GAS). Allele-replacement mutagenesis was used to construct nonpolar (in-frame) deletion mutations in the slo and sagB genes of the serotype M5 GAS strain Manfredo, producing isogenic single and double SLO- and SLS-defective mutants. In contrast to recent reports on...

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PMID: 12819070
DOI: 10.1128/iai.71.7.3857-3865.2003

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