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Article

Human Neuronal Calcium Sensor-1 Protein Avoids Histidine Residues To Decrease pH Sensitivity.

The journal of physical chemistry. B - 26 Jan 2017

Gong Yehong, Zhu Yuzhen, Zou Yu, Ma Buyong, Nussinov Ruth, Zhang Qingwen

Abstract excerpt

pH is highly regulated in mammalian central nervous systems. Neuronal calcium sensor-1 (NCS-1) can interact with numerous target proteins. Compared to that in the NCS-1 protein of Caenorhabditis elegans, evolution has avoided the placement of histidine residues at positions 102 and 83 in the NCS-1 protein of humans and Xenopus laevis, possibly to decrease the conformational sensitivity to pH gradients in synaptic...

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Identifiers

PMID: 28030949
DOI: 10.1021/acs.jpcb.6b11094
PMCID: PMC6413881

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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