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Article

The stability and activity of human neuroserpin are modulated by a salt bridge that stabilises the reactive centre loop.

Scientific reports - 2 Sept 2015

Noto Rosina, Randazzo Loredana, Raccosta Samuele, Caccia Sonia, Moriconi Claudia, Miranda Elena, Martorana Vincenzo, Manno Mauro

Abstract excerpt

Neuroserpin (NS) is an inhibitory protein belonging to the serpin family and involved in several pathologies, including the dementia Familial Encephalopathy with Neuroserpin Inclusion Bodies (FENIB), a genetic neurodegenerative disease caused by accumulation of NS polymers. Our Molecular Dynamics...

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PMID: 26329378
DOI: 10.1038/srep13666
PMCID: PMC4556959

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-26329378-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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