Article
Disorder in a two-domain neuronal Ca2+-binding protein regulates domain stability and dynamics using ligand mimicry.
Cellular and molecular life sciences : CMLS - 1 Mar 2021
Staby Lasse, Kemplen Katherine R, Stein Amelie, Ploug Michael, Clarke Jane, Skriver Karen, Heidarsson Pétur O, Kragelund Birthe B
Abstract excerpt
Understanding the interplay between sequence, structure and function of proteins has been complicated in recent years by the discovery of intrinsically disordered proteins (IDPs), which perform biological functions in the absence of a well-defined three-dimensional fold. Disordered protein sequences account for roughly 30% of the human proteome and in many proteins, disordered and ordered domains coexist....
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