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Article

Computational Tools for Interpreting Ion Channel pH-Dependence.

PloS one - 1 Jan 2015

Sazanavets Ivan, Warwicker Jim

Abstract excerpt

Activity in many biological systems is mediated by pH, involving proton titratable groups with pKas in the relevant pH range. Experimental analysis of pH-dependence in proteins focusses on particular sidechains, often with mutagenesis of histidine, due to its pKa near to neutral pH. The key question for algorithms that predict pKas is whether they are sufficiently accurate to effectively narrow the search for...

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Identifiers

PMID: 25915903
DOI: 10.1371/journal.pone.0125293
PMCID: PMC4411139

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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