Article

pH-Dependent Membrane Binding Specificity of Synaptogyrins 1-3 Provides Mechanistic Insights into Synaptic Vesicle Regulation and Neurological Disease

2025-03-10

Abstract excerpt

Synaptogyrins (SYNGRs) are integral synaptic vesicle proteins that contribute to neurotransmitter release and synaptic plasticity. Alterations in vesicular pH, as observed in ageing and Alzheimer’s disease, may influence synaptogyrin function, yet the molecular mechanisms remain poorly understood. We compared synaptogyrin-1 (SYNGR1, pI 4.5) and synaptogyrin-3 (SYNGR3, pI 8.4), two structurally similar isoforms wit...

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Literature Corpus work: ed85479c-3eac-58e3-83b6-21aecd8ba752
DOI: 10.1101/2025.03.03.641025

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pH-Dependent Membrane Binding Specificity of Synaptogyrins 1-3 Provides Mechanistic Insights into Synaptic Vesicle Regulation and Neurological DiseaseDOI 10.1101/2025.03.03.641025Read

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